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Aripiprazole
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Aripiprazole

Aripiprazole is classed as an atypical (second-generation) antipsychotic. It works at a large number of sites, including receptors and transporters. The drug mediates its action by either blocking receptors (antagonist) or by binding to them and inducing an opposite response to receptor’s normal role (inverse agonist). Aripiprazole exerts its impact via various receptors including multiple subtypes of serotonin, dopamine, adrenergic, muscarinic acetylcholine and histamine receptors. It also works on serotonin, norepinephrine and dopamine transporter proteins. The drug was first approved by the US Food and Drug Administration (FDA) for use in schizophrenia in 2002.

Other names for this medication:
Aripiprazole, Abilify, Abilitat,

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Aripiprazole comes as a tablet, a solution (liquid), an orally disintegrating tablet (tablet that dissolves quickly in the mouth) to take by mouth. It is usually taken once a day with or without food. Apriprazole also comes as a tablet that contains a sensor device to take by mouth to be used in adults to provide information about how the medication is taken. Take aripiprazole at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take aripiprazole exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Do not try to push the orally disintegrating tablet through the foil. Instead, use dry hands to peel back the foil packaging. Immediately take out the tablet and place the entire tablet on your tongue. Do not try to split the tablet. The tablet will quickly dissolve and can be swallowed without liquid. If necessary, liquid can be used to take the orally disintegrating tablet.

Swallow the tablets and the tablet with a sensor whole; do not divide, crush, or chew.

The tablets that contain a small sensor come with a patch (a wearable sensor) that detects a signal from the tablet and a smartphone application (app) to display information about how you are taking the medication. The app must be downloaded onto your smartphone before you start the medication. Apply your patch to the left side of the body above the lower edge of the rib cage only when prompted by the smartphone app instructions. Do not place the patch in areas where the skin is scraped, cracked, inflamed, or irritated or in a location that overlaps the area of the most recently removed patch. Change the patch weekly or sooner, if needed. The app reminds you to change the patch and explains how to apply and remove the patch correctly. Keep the patch on when showering, swimming, or exercising. If undergoing a magnetic resonance imaging (MRI; a medical test that uses powerful magnets to take pictures of the inside of the body), remove the patch and replace it with a new one as soon as possible. If the patch causes skin irritation, remove it and tell your doctor. After you take the medication, the tablets can be detected in the body by the app within 30 minutes to 2 hours. If the tablet is not detected after ingestion, do not take another dose. Talk to your doctor if you have any questions about how to take the tablets and use the patch or smartphone app.

Your doctor may start you on a low dose of aripiprazole and gradually increase or decrease your dose depending on how well the medication works for you and the side effects you experience.

Aripiprazole may help control your symptoms but will not cure your condition. It may take 2 weeks or longer before you feel the full benefit of aripiprazole. Continue to take aripiprazole even if you feel well. Do not stop taking aripiprazole without talking to your doctor.

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To evaluate whether wearing auditory assistive devices can improve gait and dynamic balance. By contrast, Bcr-Abl-positive K562 cells were resistant to the induction of apoptosis by beta-HIVS and this compound did not suppress the kinase activity of PLK1 in these cells. These data support the hypothesis that the lung vasculature develops by both vasculogenic and angiogenic processes: a vascular network develops in situ in lung mesenchyme, which is then connected to angiogenic processes from central vessels.

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A one-electron transfer from DHP to oxidized intermediates LiP compounds I and II (LiPI and LiPII) was characterized by using a stopped-flow technique, showing that binding interactions of DHP with LiPI and LiPII led to saturation kinetics. We discuss the benefits of these national screening and referral pathways together with their limitations and further refinements. To analyze the utility of electromyographic study of the bulbocavernosus muscle.

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Plasma levels of alfentanil and etomidate in patients and their relation to compressed power spectral analysis of the EEG. Itching, burning, or pain are common symptoms at the involved areas.

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Participants received an interviewer-administered questionnaire that included questions on demographics and behaviors. Value of computed tomography for tumors of the epi- and oropharynx The purrent discharges taken from middle meatus of 36 patients were cultured for bacteria and the antimicrobial suscepility was determined.

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The economic burden related to untreated OSA is substantial, accounting for billions of dollars per year. Observation of a modulation effect caused by a microsphere resonator strongly coupled to a dielectric substrate. This article describes the trends in hospitalization and prolonged annual season of RSV hospitalizations in Yukon-Kuskokwim children from 1993 to 2004 and discusses factors associated with high rates of RSV hospitalization and the impact of interventions to decrease RSV hospitalizations in this population. Reprogramming the immune system for tolerance with monoclonal antibodies. VCE significantly changed the therapeutic management of CD patients, even in those with long-term disease.

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Selective photocleavage of DNA by anthraquinone derivatives: targeting the single-strand region of hairpin structures. Antibodies against Pseudomonas aeruginosa toxin in preparations of normal human immunoglobulin The bonding patterns of titanium to each opaque was demonstrated similar results from the predictions of alpha and delta alpha values.

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Lack of Visual Habituation in Multiple Sclerosis: An Electrophysiological Study. We present 9 patients with contact urticaria due to rubber gloves. The in vitro activity of thiamphenicol and of 11 comparative drugs against 397 recently isolated antibiotic-resistant and/or invasive pneumococci and 52 multiply-resistant MRSA including 2 VISA strains was determined.

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Matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue-specific inhibitor of matrix metalloproteinases (TIMPs), play key roles in the cyclic remodeling events that occur in the human endometrium in preparation for pregnancy. Functional imaging work has highlighted the secondary effects that damage to networks mediating alertness can have on structurally intact spatial systems.

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Collaborative evaluation of the Abbott Avantage system for identification of frequently isolated nonfermentative or oxidase-positive gram-negative bacilli. The role of distraction osteogenesis in craniofacial surgery will continue to evolve rapidly with increasing experience and technological advancement. A study of tumor motion management in the conformal radiotherapy of lung cancer. This study demonstrates that the inflammatory milieu of pre-eclampsia induces decidual cells to promote dendritic cell infiltration.

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Viscoelastic behavior and in vivo release study of microgel dispersions with inverse thermoreversible gelation. Heterosexual youth reported fewer HIV risk peers and more pro-social peers. tanashiensis DNA was analyzed by complementation tests with kalafungin-nonproducing mutants. Following his research (Wright 2002), David Wright developed this protocol for nurses to use when administering medication to patients who have swallowing difficulties. In an earlier study, we reported that a 6-h delay of sleep in normals produced REM changes that resembled the depressive pattern.

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Biogenesis of acetylcholinesterase is impaired, although its mRNA level remains normal, in the glucocorticoid-treated rat skeletal muscle. These findings may affect the management of PTSD and prognosis for this population. The internal and independent laboratory tests demonstrate that the method is rapid and sensitive for screening of the target STEC. Sensitization of pain pathways in the spinal cord: cellular mechanisms. Toxicity is significant, and the addition of radioprotectors could be desirable.

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In order to assess the potential for the spread of class IIa bacteriocin resistance in natural populations of Listeria monocytogenes, the fitness costs associated with resistance to leucocins A, B and E and sakacin A in L. 6 tibial osteotomies of valgisation, 6 tibial diaphyseal fractures, 2 fractures of the lower extremity of the femur, 2 bimalleolar fractures, 1 serious knee sprain, 1 patellar fracture, 1 calcaneum fracture and an arthroscopic arthrolysis of the knee. Nuclear and cytoplasmic vacuolization were the most frequent damage observed in the post-radiation group.

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