Ezetimibe and Cardyn combination is used together with a proper diet to treat high cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (eg, heart attack, stroke) caused by clogged blood vessels. It is also used to treat a condition called homozygous familial hypercholesterolemia (HoFH).

Ezetimibe is a cholesterol absorption inhibitor and Cardyn is an HMG-CoA reductase inhibitor, or statin. These medicines will reduce the absorption of cholesterol from foods and the production of cholesterol in your body.

This medicine was available only with your doctor's prescription.

The Cardyn/ezetimibe combination (Liptruzet(R)) was withdrawn from the United States market on June 2, 2015.

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The aggregate score then is assigned a categorical ranking that ranges from excellent to poor. Results of immunogold electron microscopy experiments are also presented. Growth of the primary Fischer bladder carcinoma (FBCa) and metastases to lungs and lymph nodes were significantly inhibited in F344 rats treated weekly with 1 mg MA.

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Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsis. This was a retrospective single-institution study of 232 patients with small- or non-small-cell lung cancer, with methodology comparable with that of the original study. Pulling back slightly the covers of the unknown in the physiology and pathology of the blood microcirculation

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Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA. Reconstitution of the active methyltransferase from inactive fragments was demonstrated in vitro, as well.

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Thermodynamic analysis of the increased stability of major histocompatibility complex class II molecule I-Ek complexed with an antigenic peptide at an acidic pH. This study was designed to investigate the sensitivity of HCC cells to TRAIL after silencing DcR3, and this was done by evaluating the expression of DcR3 in HCC cells and the effect on TRAIL-mediated apoptosis after downregulation of DcR3. Primary ascertainment of diabetic subjects was by retrospective review of hospital and clinic records, and IDDM was defined by Diabetes Epidemiology Research International Group criteria. A relapse was noted in one patient 1.5 months after oral treatment was discontinued. Through a review of the literature and our recent studies examining vascular calcification in ESRD patients, hyperphosphatemia is significantly associated with vascular calcification in nondiabetic ESRD patients, while it may not be a significant risk factor for vascular calcification in diabetic ESRD patients.

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Cardiovascular disease is the leading cause of death in the Western world with an increase over the last few decades. After 48 h, the above medium was in proportion transferred to the neuron culture medium. We show that tri-genome methylation is highly conserved with the diploid wheat progenitor while sub-genome-specific methylation shows more variation. The nanofriction between a silicon nitride probe and both a silicon wafer and an octadecyltrichlorosilane (OTS)-coated surface is studied in saline solution by using lateral force microscopy (LFM). It seems that the combination of FS and APRI does not significantly improve the ability to predict significant fibrosis.

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There is growing evidence that the etiology, pathophysiology, prognosis, and response to treatment may all be different in women. We further show that HIV-1 gp120 triggers the association of CD4 with FAK in T cells, under conditions that are known to dissociate Lck from CD4. Patients randomly received either a disposable nasal or an oronasal mask (Respironics, Pittsburgh, PA) when they met study criteria. Early nasal endoscopy with biopsy and initiation of appropriate therapy are necessary to improve prognosis. One of the secondary injury factors implicated in the development of irreversible tissue injury, and associated mortality and morbidity after neurotrauma, is magnesium.

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Late results of surgical treatment of children with rheumatoid arthritis Substituent Effects on Cytotoxic Activity, Spectroscopic Property, and DNA Binding Property of Naphthalimide Derivatives. Acebutolol and diacetolol plasma levels in patients undergoing myocardial revascularization with hypothermic cardiopulmonary bypass. The mean difference in refraction between the monozygotic twins was significantly lower than that between dizygotic twins (p less than or equal to 0.001). Neglected aspects of the antialcoholic iconography: lantern slides and film strips

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Operative treatment of the retroauricular opening remaining after radical operation of the ear. Sensitivities of wild-type and envelope-defective strains of Escherichia coli and Pseudomonas aeruginosa to antibacterial agents. Endogenous prostaglandin endoperoxides and prostacyclin modulate the thrombolytic activity of tissue plasminogen activator. Modulations by taurine of the spontaneous action potentials in right atrial muscles of rats.

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Pharmacologic hemostasis in prostatectomy using the Hribar-Weber technic Characteristics of and risk factors for pneumonia in patients with hematological malignancies developing fever after autologous blood stem cell transplantation. Quantitation of antibody reactivity to human immunodeficiency virus (type 1) proteins and glycoproteins on Western immunoblots by reflectance densitometry.

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A study was made on the effects of DL-dihydrolipoate, lipoate and iron-sulfur proteins on the activity of rhodanese (EC 2.8.1.1) with dihydrolipoate or cyanide as acceptors. Continent urinary diversion and the exstrophy-epispadias complex. The antihypertensive actions of CGS 16617 also were potentiated by the cyclooxygenase inhibitor indomethacin, a result suggesting that CGS 12970 may enhance the action of CGS 16617 by inhibiting the action of vasoconstrictor prostaglandins produced after administration of an ACEI. Subject acceptance of this new combination oral contraceptive was high.

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Using a between-group mean difference of 5 Roland-Morris Disability Questionnaire points, a previously validated threshold for clinical significance, we calculated the need for at least 100 patients with primary outcome data. Methods and Results Between 2008 and 2011, the Belgian development aid agency (BTC) launched a set of reforms in the Kisantu district, in the province of Bas Congo, through an action-research process deemed appropriate for the implementation of change within open complex systems such as the Kisantu local health system.

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Post-transplantation-emerging anti-HLA DQA1/DQB1 antibody possibly responsible for graft rejection after myeloablative-unrelated marrow grafting. To investigate the apoptosis induced by diacetyldianhydrogalactitol (DADAG) and its mechanism in human HL-60 leukemia cells. Coexistence cannot occur under classical interference competition even when the species inferior at resource exploitation is superior at interference.

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Hypothalamic and pituitary endo-oligopeptidase B activity was shown to be present predominantly in the soluble fraction of the enzyme preparations. The rats responded almost exclusively on the PCP-appropriate lever after ketamine and on the saline lever after morphine and d-amphetamine, indicating pharmacologic specificity. An appropriate neuroradiologic or electrophysiologic procedure done at this point will usually provide the correct diagnosis.

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Measures of psychological well-being and treatment satisfaction developed from the responses of people with tablet-treated diabetes. Nine cynomolgus monkeys underwent right-sided frontotemporal craniectomy and placement of a semipermeable microdialysis catheter adjacent to the right middle cerebral artery (MCA). A contribution to the problem of treatment of lupus with vitamin D2 and Finsen light. In light of these circumstances, it is important to have an updated understanding of the costs of CF therapy and management.

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N-terminal proB-type natriuretic peptide (NT-proBNP) concentrations in elite rugby players at rest and after active and passive recovery following strenuous training sessions. The first step in the international approach to the problems of underdeveloped areas.

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Acid and pepsin secretion in concomitant gastric and duodenal ulcers was significantly higher than in case of gastric ulcer alone, and similar to the secretion seen with duodenal ulcer. Comparative studies of the clearance of inulin and creatinine in swine Although other vasodilators have been shown to be anti-arrhythmic, ACE inhibitors also raise serum potassium levels and this may therefore be of importance to their anti-arrhythmic activity. Our randomized trial investigated duration of cryotherapy (2 and 6 h) for reduction of mucositis prevalence and severity and explored factors associated with variability in pharmacokinetics and outcomes from melphalan therapy.

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Forest-fire smoke inhaled by humans can cause various health effects. Furthermore, not all precipitating antigenic components appear to play a role in the detection of antibodies against A. However, in recent years, an unexpected complexity in the mechanisms of macrophage accumulation in lesions, in the protective and pathogenic functions performed by macrophages and how they are regulated has been uncovered.

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In the Drosophila embryo, the glial cells of the peripheral nervous system are generated both by central neuroblasts and sensory organ precursors. Significance of myocardial prostaglandin biosynthesis and the influence of mechanical loading, endogenous mediators and cardiovascular drugs. Neuronal differentiation is a multistep process that shapes and re-shapes neurons by progressing through several typical stages, including axon outgrowth, dendritogenesis, and synapse formation. Significant abnormalities of motor coordination persisted for more than 12 months in most members of the Everest expedition. This study demonstrates for the first time the importance of titin-based restoring force in length-dependent deactivation during the early phase of diastole.

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Protection by streptomycin, penicillin and licheniformin against c. This paper first found mutations of Nogo-C in HCC patients from Qidong in China: A172G (Thr58Ala), A340G (Arg114Gly), A571G (Ile191Val). The results imply that it is important to reinforce both domestic and international quarantine to control the spread of pinewood nematode. Our results suggest that it is the combined effect of the oxygen concentration and matrix density that creates an environment where the glycolytic phenotype has a growth advantage and consequently is most likely to appear. Previous studies suggested a potential role for macrophage colony stimulating factor (CSF-1) in lactogenic differentiation of the breast.

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The second aim was to test to what extent the same sensory and neuronal mechanisms would be adequate also for controlling the front and hind legs, despite the large differences in both leg morphology and kinematic patterns. The study results provide evidence that ascending aortic aneurysm in patients with BAV differs clinically and histologically from that in patients with tricuspid aortic valve.

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Agar-well determined Minimum Inhibitory Concentration (MIC) values ranged between 3.125 mg/ml and 6.25 mg/ml while the disc diffusion determined MIC values ranged between 6.25 mg/ml and 25.0 mg/ml. A formula was derived that makes it possible to calculate the in vivo (preexcision) specimen diameter from the in vitro (fixed-tissue) specimen diameter.

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Ericson fluctuations in the chaotic ionization of the hydrogen atom in crossed magnetic and electric fields. A significant drop in the total cholesterol level was found in normocholesterolaemic Wistar rats after the administration of cholestenone. Continent ileocecal diversion with an unaltered in situ appendix conduit. rTMS of DLPFC in TRD patients leads to remote temporal hypoperfusions in relation with changes in functional connectivity between the DLPFC and the default mode network, especially including medial temporal limbic areas. Meat consumption, N-acetyl transferase 1 and 2 polymorphism and risk of breast cancer in Danish postmenopausal women.

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Experiments on the holding powers of various types of metallic internal fixation for transcervical fractures of the femur. Interestingly we have found evidence for only two tandemly linked PGK genes which correspond to the PGK gene B and C homologue in Trypanosoma and Crithidia. Results support the potential for other applications in residency and continuing education. Tyrosinase-positive albinos or near-albinos are known at a number of loci in mice and other mammals.

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Characterization of a chemotactic defect in patients with Kartagener syndrome. Hindlimb and tail irradiation did not induce changes in the morphology of the thymus and the phenotype of the thymocytes. Posterior open wedge osteotomy of the scapula neck for the treatment of advanced shoulder osteoarthritis with posterior head migration in young patients. The effects of various operating conditions such as carbon sources, temperature, and pH on the reduction rate were studied.

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Such a program offers the users the opportunity to acquire a deeper understanding of the system and avoid potential pitfalls. Prenatal cocaine exposure (PCE) is associated with increased rates of illicit-substance use during adolescence. These results form the basis of a larger scale randomized clinical trial. Nicotinamide (10 mM), a reaction product of ADP ribosylation, reversed cholera toxin-induced secretion, restoring absorption. Apolipoprotein and apolipoprotein receptor genes, blood lipids and disease.

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A next development step is to implement and test blended treatments using video conferencing inside the platform. Transfectants in which the heavy chain lacking the hydrophobic leader was expressed together with a light chain carrying the nuclear localization signal were selected and a nuclear distribution of the assembled antibody was found. The nearest neighbor criterion was useful in a CAD scheme for determining the histological classification.

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The experimental results are in good agreement with predictions. The wounds healed by first intention in 19 cases, the free skin graft necrosed partially in 1 case and healed by second intention after dress-changing. In the past years, the structure and function of the plasma lipoproteins and apolipoproteins have been elucidated.

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Objective The objective of this research was to better understand the perceptions of responders and decision-makers regarding disability and efforts to address the needs of PWD following the 2010 earthquake. The analysis resulted in the identification of polyketide-peptide antibiotics, namely corallopyronin A and B (K9-5) and myxalamid B and C (V3-1), which were responsible for important Gram-positive activity in the observed strains. No polymerase II enzyme was detected in isolated metaphase chromosomes.

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NADPH-diaphorase histochemistry was used to determine the activity of NOS (nitric oxide synthase) in mesenteric vascular beds. JCMS virulence correlates with intestinal distension and bacterial accumulation and requires the bacteria to be alive. NELL1 is an extracellular protein inducing osteogenic differentiation and bone formation of osteoblastic cells. Specifically, training increased the distributed multi-voxel pattern information for trained object distinctions in object-selective cortex, resulting in a generalization from pre-training multi-voxel activity patterns to after-training activity patterns. A number of diverse gene therapy strategies are being evaluated in the search for novel therapeutic approaches to hematopoietic disease.

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A novel lineage-specific nuclear factor regulates mb-1 gene transcription at the early stages of B cell differentiation. Peroneus tertius tendon repair following old traumatic rupture of the anterior tibial tendon (casuistry) The achaete-scute complex (AS-C) and the daughterless (da) genes encode helix-loop-helix proteins which have been shown to interact in vivo and to be required for neurogenesis. To investigate the relationship between these two forms of learning, we consider a special case in which they are identical: a multilayer perceptron with linear output units, to which weak feedback connections have been added. Over a 24-hour period, blood was drawn from the study participants every 20 minutes for determination of growth hormone.

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Valve surgery in elderly patients 70 years or older: early and late results. Dwarf males were most related to their host shoot, then their colony (within 0.5 m(2)) and then the rest of the population, which suggests restricted spore dispersal.

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These receptors exceed the physiological performance of other crustacean mechanoreceptors in sensitivity to water velocities as well as in frequency response. However, prospective investigations evaluating obesity and pelvic organ prolapse are few. Comparison of the N-linked glycosylation of Sec12p, a Sec12p-invertase hybrid protein, and a derivative of Sec12p lacking 71 carboxy-terminal amino acids showed that Sec12p is a type II membrane protein. We used a prospective cohort database to examine differences in patients stratified according to age of onset. To give the histological results of the operated atypical renal cysts and to establish a correlation between the radiological findings and histological features.