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Alvastin (Atorvastatin)
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Atorvastatin

We studied the effects of statins (Alvastin and simvastatin) on human DC maturation and T-cell activation. These results suggest that Alvastin may inhibit both rapamycin-sensitive and rapamycin-insensitive mechanisms of tuberin-null cell growth, likely via Rheb and Rho inhibition, respectively.

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Alvastin is used together with diet, weight loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Alvastin is also used to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol ('bad cholesterol') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol ('good cholesterol') in the blood. Alvastin may also be used to decrease the amount of cholesterol and other fatty substances in the blood in children and teenagers 10 to 17 years of age who have familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol cannot be removed from the body normally). Alvastin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats with Alvastin has been shown to prevent heart disease, angina (chest pain), strokes, and heart attacks.

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L-Arginine catabolism was studied in suspensions of canine cortical proximal tubules, medullary thick ascending limbs, and papillary collecting ducts either incubated without exogenous L-arginine being added (small endogenous quantities) or incubated with L-arginine being added in supraphysiological amounts (2 mmol/L with or without the presence of alternative metabolic substrates, 2 mmol/L L-glutamine, or lactate). The concept of allostatic load holds promise for nursing researchers to operationalise a holistic view of multiple stressors and to quantify their effects on health. To identify proteins interacting with human 5LO, we used a two-hybrid approach to screen a human lung cDNA library. These infants are at high risk for multiple problems including growth delays, nutrition and feeding problems, pulmonary sequelae, neurological sequelae and developmental delays, vision and hearing disturbances, as well as abnormalities in parent-infant bonding.

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Nerve growth factor appears to have a major role during skin injury, e.g., preventing melanocyte apoptotic cell death following UV irradiation. The effect was not restricted to cortical areas known to be involved in articulatory speech programming or rehearsal processes (the inferior frontal gyrus and anterior insula), but also extended to areas associated with other aspects of language processing (inferior parietal cortex) associated with phonological processing and storage. To evaluate the safety and efficacy of the inside-outside technique for occipitocervical stabilization used to manage rheumatoid patients.

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Disrespectful Behavior in Health Care: Its Impact, Why It Arises and Persists, And How to Address It-Part 2. Using this assay and a previously described EIA for AcSDKP, a negative regulator of pluripotent haematopoietic stem cell proliferation, the levels of these two peptides were determined in mouse tissue extracts. Whether heparin is necessary for the maintenance of locks composed of other materials is uncertain. Supercritical fluid assisted process for the generation of cellulose acetate loaded structures, potentially useful for tissue engineering applications. Secretory granules were hypodense with less active lysozyme, and there was evidence of autophagosome accumulation and granule degradation in PCs from ZnT2ko mice.

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An appropriate balance of extracellular matrix synthesis and degradation is required for normal morphogenesis and maintenance of tissue architecture. The average breaking strengths of the 10 Dicor crowns were compared to that of 10 metal ceramic control restorations. Central and peripheral control of postprandial pyloric motility by endogenous opiates and cholecystokinin in dogs.

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Drug-dependent mental patients often fail to obtain adequate psychiatric care Lack of association between human leukocyte antigens and the anti-Hu syndrome in patients with small-cell lung cancer. It is often necessary to remove the contaminant by flushing the bags with pure nitrogen or air. Moreover, the development of both viral infection and other disease was frequent.

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In a habituation test in the mouse, ondansetron facilitated performance in young adult and aged animals, and inhibited an impairment in habituation induced by scopolamine, electrolesions or ibotenic acid lesions of the nucleus basalis magnocellularis. Non-fatal suicidal behaviours and thoughts are indicators of increased risk for future suicide. We studied the metallothionein content of 9 human transitional cell carcinomas of the bladder with immunohistochemical methods. The present study aimed to investigate perinatal outcomes and to describe antenatal factors for development of preeclampsia (PE) in patients with isolated proteinuria in pregnancy.

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Our findings favour an increased pro-serotoninergic effect after TSD, which comprises respective variations of the host defense system, but is abolished by consecutive recovery sleep. Patients in the PEP group had significantly better Mental Health scores after 1 month and significantly better Bodily Pain scores after 6 months compared with patients who received standard care. Concurrent validity of a brief self-report Drug Use Frequency measure. Commercial broiler chicks were fed from 7 to 49 d of age on 15 experimental diets which varied in their concentrations of tannins and animal fat (tallow), by the inclusion of different amounts of high and a low protein varieties of sorghum. Overall, 42 eligible meta-analyses were included in this review, in which meat consumption was assumed from sheer statistics.

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Using computer simulations, we have examined the output generated by the lamprey model network for different input drives. Local indistinguishability: more nonlocality with less entanglement. Unexpected lower testosterone in faster growing farmed saltwater crocodile (Crocodylus porosus) hatchlings.

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This study demonstrated that microspectroscopic techniques may be used to rapidly identify both microbial particles and inorganic precipitates in the cell culture media. The cytoskeleton-disrupting drugs that inhibit actin polymerisation were used to investigate the mechanism of capping of HLA-DR molecules. Existing studies have tried to detect an association between phathalic acid esters (PAEs) and PP, but the results did not reach a consensus.

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We found that lower concentrations of MEL 174 (final water extract of RJ) and MEL 147 (3-10-dihydroxydecanoic acid) stimulated T-cell proliferation, triggered by concanavalin A (Con-A) and the process was followed by an increase in the production of interleukin-2 (IL-2). Functional requirement of CCN2 for intramembranous bone formation in embryonic mice. Y2/3H interaction studies showed that SmTK6 binds with its SH2 domain to a specific binding motif within the C-terminus of SmOPG1.

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Such an invasive process is often associated with the rearrangement of fibroblasts, marked changes in the production of collagen and proteoglycans of the extracellular matrix and lysis of the existing structures of the colonic wall. Workshop report: evolutionary immunobiology--new approaches, new paradigms.

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Expression of human endogenous retrovirus-K is strongly associated with the basal-like breast cancer phenotype. Without evidence of toxicity, wsSCLE treatment decreased lipid accumulation compared with the untreated adipocyte controls as shown by the lower absorbance of Oil Red O stain. Self-organizing systems such as these can be accounted for by the concept of stigmergy which describes self-organization that emerges through indirect communication via persistent signals within the environment. These changes were statistically significant, but there was no significant change in arterial pH in any of the obstructed groups.

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These findings suggest that TRH and CNK-602A augment LTP in the mossy fiber-CA3 pathway without activating noradrenergic and/or dopaminergic fibers. Diagnosing herpesvirus infections by real-time amplification and rapid culture. The interviews with case and control series covered detailed questions on frequency of consumption of various dietary items and socio-demographic characteristics. To provide experimental evidence for improving clinical management of TCCs, two human TCC cell lines, EJ and BIU, were treated for 1 or 2 h by 50, 100, 150 and 200 micro g/ml, respectively and their growth and death patterns were elucidated in 12-h intervals.

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Floret-like multinucleated giant cells have been reported in gynaecomastia and neurofibroma in neurofibromatosis type 1. The most senior nurse on duty was interviewed about each resident sampled, and optionally about their own training and experience. At the same time changes in neural membrane excitability as well as neural responses evoked by tactile stimulation of snail foot or chemical stimulation of snail head were similar with ones in control snails. Various evidence has demonstrated a role of the nitric oxide (NO)/cGMP signaling pathway in the processing of nociception. By sequential transition metal deposition and sulfurization procedures, a WS2/MoS2/WS2 double hetero-structure is demonstrated.

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The renin-angiotensin system (RAS) was initially considered as a circulating humoral system, which function is the regulation of blood pressure. After a serum-free period corresponding to one doubling cell time, cells were incubated with 100 to 1,200 pM G-17, 40 or 80 mM proglumide, and 2.5 to 5 micrograms/ml enprostil for 8 h. We further demonstrate that a large subset of PDZ domains in mammalian genomes are capable of binding to PI lipid membranes, indicating that lipid binding is the second most prevalent interaction mode of PDZ domains known to date.

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The aim of this longitudinal study was to evaluate the association between occupational stress and metabolic syndrome (MetS) in a rapid response police unit. To determine the frequency and determinants of subnormal global cognitive function in a representative, community-based sample of children prospectively identified at the time of initial diagnosis of epilepsy. Performance and specificity of monoclonal immunoassays for cyclosporine monitoring: how specific is specific? Drug therapy included: muscle relaxants and tranquilizers while orthopedic treatment meant plastic immobilization. A constant value of density generated a clear onset, but a wide distribution of it corresponding to peripheral airway closure obscured it.

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At weaning, cinnamon male pups exhibited lower insulinemia, whereas cinnamon female pups exhibited lower glycemia. The cornerstones of the guideline are the preoperative identification and handling of patients at risk, adequate intraoperative care, postoperative detection of delirium and management of delirious patients.

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Sarcopenia might not affect short-term outcomes in patients with early-stage lung cancer. Various approaches have been proposed to break down technical barriers in Li-S battery systems. Retinoic acid (RA) plays a major role in neuronal cell differentiation. This underscores the need to understand the effects of the underlying risk function assumed when interpreting simulated outcomes of intervention strategies.

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Using amplified fragment length polymorphisms (AFLPs), we analyzed the genetic structure of wild and domesticated common bean (Phaseolus vulgaris L.) from Mesoamerica at different geographical levels to test the hypothesis of asymmetric gene flow and investigate the origin of weedy populations. Ultrastructurally the follicular cells contained large residual bodies composed of abundant electron-lucent lipid droplets of variable size. We previously discovered that the expression of the tumor suppressor phosphatase and tensin homolog (PTEN) was downregulated in the majority patients with tongue squamous cell carcinoma (TSCC). Hybrid males and females produced songs which are distinctly different from parental songs and these differences can be attributable to genetic factor. Free Energy Landscape of Protein-Protein Encounter Resulting from Brownian Dynamics Simulations of Barnase:Barstar.

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During the last decade, the intense study of adult hippocampal neurogenesis has led to several new lines of inquiry in the field of psychiatry. Twenty-eight patients cured of testicular cancer by cisplatin-based chemotherapy were asked for their own views of the long-term psychological and social effects of their treatment. Cytoplasmic proteins from rat skeletal muscle tissue were fractionated into four groups according to their different isoelectric points: fraction A (pI 9.5-7.0), B (pI 7.0-5.6), C (pI 5.5-4.5) and D (pI 5.3-3.5). The grandmother (I-1) died at the age of 16 years two months after her first birth. The mean excretion of 6H5MI2C was 42.8 mumol/mol creatinine at 5 years of age and 26.1 mumol/mol creatinine at the age of 15.

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Unimproved water sources (wells, water streams and water tanks) are significantly associated with T. Thereafter, CT did not reveal any growth of the mass, but to examine the mass in detail he was hospitalized to our department. Radio frequency radiation (RFR): the nature of exposure and carcinogenic potential. In contrast, hydralazine decreased pulmonary vascular resistance index and increased cardiac index and RV ejection fraction. In the recent decades of the study, the incidence and the prevalence rates showed a relative increase.

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A distinct difference was found in the surface binding affinities of immunoglobulin (IgA) from different glandular salivas. It is concluded that both Ulex europaeus agglutinin and laminin antisera could be valuable new aids for the diagnosis of the three tumor types.

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In this case, close observation using cytology and colposcopy along with colposcopically directed excisional biopsy postponed the need for more aggressive intervention, while minimizing possible disruption of the pregnancy and danger to the mother and infant. Reversible hearing loss is an infrequently described adverse effect attributed to high-dose erythromycin therapy. We aimed to assess the type of problems that committees encounter with psychiatric research, using a postal survey of 211 LRECs. There was a significant correlation observed between the changes of gastric motility and LF/HF ratio in response to EA. Adding the indirect CVD costs associated with productivity losses at work and home can result in forecasted cost savings to society as a whole such that lipid therapy could potentially save lives and money.

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We find that the evolution trajectory of the wave packet depends sensitively on its initial spin state. Interrater reliability, assessed by having two raters analyze 16 mother-child dyads, proved satisfactory. Secondary osteoplasty in the mixed dentition in clefts of the lip, jaw and palate

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The lamb lung has several key features conducive to modeling RSV infection in human infants, including susceptibility to human strains of RSV such as the A2, Long, and Memphis Strain 37 (M37). Melasma is a common challenging pigmentary skin disorder especially in dark-skinned females urging them to seek medical help. The transition from high school to college entails a change in legal status for individuals with learning disabilities.

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Renal cell carcinoma (RCC) is one of the most drug-resistant malignancies in humans. The results were analysed in the context of tuberculin reactivity and X-ray findings. In turn, MarA enhanced repression of hdeAB by H-NS and hindered activation by GadE in stationary phase and also reduced the activity of GadX, GadW, RpoS, and Lrp on hdeAB under some conditions. Via RTPCR the cDNA sequence of the full length ZC376.5 has now been cloned, expressed in Escherichia coli and demonstrated to encode a tRNA(m2/2G(26))dimethyltransferase that produces dimethyl-G26 in vivo and in vitro with tRNA from yeast and bacteria as substrates.

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In the other groups of women, general chemistries and selected hormone assays were carried out on samples from 30 subjects who had used the implants for 51 months and from 24 subjects who had used the TCu 200 IUDs for 43 months. High frequency ultrasound study of skin tumors in dermatological and aesthetic practice. According to the studies in our laboratory, it was suggested that the complement activation and neutrophil aggregation induced by C5a and mediators released by it and other way are likely to be the initiation factors. Although there was some reduction in activity at pH 4 versus 7, the resulting MIC values were still well below the intravaginal CD101 drug concentrations anticipated to be present following topical administration. The expression of these genes was assessed by two single-copy independently arranged chromosomal-based reporter systems, beta-galactosidase agr-P3 promoter fusion and a lux-tst promoter fusion.

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If a governmental agency or an insurer is going to restrict dispensing, then, based on current credentials, audiologists should always be one of the groups permitted to dispense. Extramedullary plasmacytoma presented with multiple pulmonary plasmacytoma as first manifestation: a case report and literature review Statistically detecteable changes were found in the diabetic vessels in the early stage of the diabetes.

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Long-range ferromagnetic dipolar ordering of high-spin molecular clusters. Teamwork, meet physiological changes of aging and how these affect the response to drugs, atypical presentation of illness and keep in mind the importance of psychosocial and environmental issues both in presentation and in addressing and monitoring of disease. A series of 122 patients with ulcerative colitis and a matched hospital control population were independently studied by a team of physicians and a team of psychologists. The first report indicated an increase in cancer mortality, while a subsequent publication with the same lead author claimed no increased risks. There remain polarized views on the best surgical approach to malrotation yet a persistent belief in the reduction in postoperative adhesions in leading to a postoperative volvulus with LL procedures.

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Exercise groups in an insight-oriented, evening treatment program. The human blood platelet as a model for studying interactions of ethanol with membrane lipids. Conversely, mitochondrial gene flow is more extensive between non-African populations, but appears to be absent between European and Asian populations. The present study will hopefully contribute to microdissection of the chromosomal region of the SMA gene.

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The water-soluble NADH dehydrogenase fragment has a molecular mass of approximately 170,000 Da and consists of the subunits NuoE, F, and G. A further case of anti-Lutheran immunization, with some studies on its capacity for human sensitization. Reliability of the Roenigk classification of liver damage after methotrexate treatment for psoriasis: a clinicopathologic study of 160 liver biopsy specimens. As development of branches proceeds, RFL RNA accumulation localized in the developing branches except for the apical meristems of the branches and secondary branch primordia. In this study it was examined whether orthopedic rehabilitants with versus without a comorbid mental disorder profit from inpatient orthopedic rehabilitation to the same degree.

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The following spring, analysis of songs revealed that siblings reared in acoustic isolation produced normal song structures, including larger syllable repertoires than those exposed to song. After iatrogenic crystalline lens injury, capsular damage could remain quiescent or progress to cataract formation.

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Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2. Tyrosine phosphorylation of ErbB-2 is involved in regulating the androgen-responsive phenotype of prostate cancer cells, and it is at least partly regulated by the cellular form of prostatic acid phosphatase (PAcP), a prostate-unique protein tyrosine phosphatase. Association among Emergency Department Volume Changes, Length of Stay, and Leaving Before Treatment Complete.

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albicans and consequently decrease the expression of the HWP1 gene. Antibody responses to meningococcal polysaccharide vaccine in adults without a spleen. In certain selected cases, placing an intracranial carotid stent, without previous balloon dilatation, can give good results and prevent the complications that can accompany angioplasty (such as dissection, rupture or embolism) A complicated multisystem flare of systemic lupus erythematosus during pregnancy.

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Numerous studies show that mitochondrial energy generation determines the effectiveness of immune responses. Here, we provide a conceptual basis for examining the importance of cancer cell-cancer cell interactions to the behaviour of tumours and propose specific mechanisms by which clonal diversity in tumours, including that provided by EMTs, can drive the progression of tumours to malignancy. Premedication with OTFC and local anesthetic prior to incision or wound closure.

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Replacement of teicoplanin with vancomycin led to full recovery of both patients and their discharge from hospital. The results support that HOXC10 is a key negative regulator of the process esomeprazole tad 40 mg beipackzettel citalopram of browning in white adipose tissue. Detection of microdeformations and photoelastic stress analysis served as the examination method.

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A short clinical course was usually related to an early onset of prominent nervous symptoms, while prolonged cases expressed fewer nervous signs. A complaint of pain during mitomycin administration should prompt immediate cessation of infusion and regular frequent follow-up. The interstitial nephropathy is usually due to the consumption of non steroidal anti-inflammatory drugs, and it is characterized by ecoprofen 600 mg interstitial lesions associated with minimal glomerular lesions. Stochastic dynamics of microtubules: A model for caps and catastrophes.

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The aim of this study was to test the efficacy of a GnRH vaccine in elephant bulls for suppressing the HPG axis and mitigating musth-related aggressive behavior. This paper explores how to make an efficient choice of analysis based on clindamycin macrolide cross reactivity allergy individual patient summary statistics. Event-related brain potentials, electromyogram, and continuous response measures showed that responses could be interrupted at any time.

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Theory of solvation-induced reentrant phase separation in polymer solutions. The SGK1 inhibitor SI113 induced a significant reduction of endometrial cancer cells viability, measured by the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Sagittal trazodone withdrawal how long fast gradient echo cine MR images of the supra-glottic airway were obtained with a 1.5T MRI scanner on seven children with tracheotomy tubes. This nonsense mutation, Q665X, results in a termination codon in the epidermal growth factor (EGF) precursor homology domain of the mature LDLR.

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All normal subjects had a fasting breath hydrogen concentration of less than 20 ppm. In contrast, GnRH or antide did not have a clindamycin penicillin allergy significant effect on TIMP-1 mRNA level in these primary cell cultures at any of the concentrations used in these studies. These data demonstrate new aspects of heterogeneity within the rat thymic cortical population. Class II antigen expressing cells in experimentally induced pulpitis. Protection against rotavirus diarrhoea in mice by trypsin inhibitor.

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On the other hand, virtually no intensely positive cells were detectable in cerebellar cultures at any period examined up to 21 days. It still remains unknown how BiP affects the protein folding pathway and there has been no direct demonstration showing which folding state of the substrate protein is bound by BiP, as overdose on xanax and zoloft side previous work has used only peptides. General medical burden was assessed by completing the Cumulative Illness Rating Score (CIRS) from chart review. In the past decade, an explosion of interest in pediatric pain has resulted in the proliferation of research studies.

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Pathobiology of cholesterol gallstone disease: from equilibrium ternary phase diagram to agents preventing cholesterol crystallization and stone formation. This B cell response was reduced by the synthetic corticosteroid TA at a tramadol withdrawal depression concentration of 10(-6) M.